SOLUBILIZING PROPERTIES OF HYDROPHILIC COLLOID FROM ANACARDIUM OCCIDENTALE L. EXUDATES IN PARACETAMOL LIQUID PREPARATION
Olorunsola EO*, John UE
Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria
Afr. J Pharm Res Dev; Volume 8(2): 147-152 ; Nov/Dec 2016
Hydrophilic colloids generally possess mild to moderate surface activity. The solubilizing properties of cashew gum (CSG) in paracetamol liquid preparation were investigated in this study. Solubilities of paracetamol in purified water and in 0.25, 0.50, 0.75, 1.00, 1.50 and 2.00 %w/v CSG dispersions were determined. Solubilities of the drug in 1.00 %w/v gum dispersion at 30, 40, 50, 60 and 70 °C and at pH range of 1 to 8 were also determined. The impact of Tween® 80 (T80) as a co-solubilizer was equally determined. Similar parameters were obtained for dispersions of acacia gum (ACG) for comparison at equivalent concentrations. Paracetamol had solubility of 22.4 g/L in 1.00 %w/v CSG and 20.0 g/L in same concentration of ACG. Increase in temperature had greater effect on drug solubilization in acacia gum dispersion. Solubilities of paracetamol in dispersions of the two gums were comparable between pH of 1 and 5. At higher pH, solubility in dispersion of ACG was higher than in CSG. Solubility of the drug in dispersion containing 0.02 %w/v Tween® 80 and 1.00 %w/v CSG was 52.0 g/L while it was 30.4 g/L in dispersion containing 0.02 %w/v Tween® 80 and 1.00 %w/v ACG. This study has shown that 1.00 %w/v CSG dispersion has higher solubilizing power compared to same concentration of ACG at room temperature. Cashew gum dispersion at this concentration can be used to prepare 112mg/5ml (maximum concentration) paracetamol solution while a dispersion containing 1.00 %w/v CSG and 0.02 %w/v Tween® 80 is suitable for preparing 250mg/5ml paracetamol solution.
KEYWORDS: Cashew gum, Solubility, Solubilizing properties, Paracetamol
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