QUALITY ASSESSMENT OF FIFTEEN DIFFERENT BRANDS OF CIPROFLOXACIN HYDROCHLORIDE TABLETS MARKETED IN ANAMBRA STATE, NIGERIA
Uduma E. Osonwa, Sunday O. Abali, Kingsley I. Chukwu, Kingsley E. Udensi
- Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
- Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, East-West Rd., Choba, Port Harcourt, Rivers State, Nigeria.
- Department of Pharmaceutics, College of Pharmacy and Nutrition, University of Saskatchewan-Canada
Afr. J Pharm Res Dev; Volume 8(1): 01-08; June/July 2016
This work is aimed at comparatively assessing the quality of 15 registered brands of ciprofloxacin tablets marketed in Anambra State, South eastern Nigeria. The physicochemical properties of fifteen brands of ciprofloxacin tablets marketed in the state were compared. The distinguishing features were noted and several parameters such as weight uniformity, crushing strength, friability, disintegration, assay of the content of active ingredients and dissolution were assessed using the methods described in the British Pharmacopoeia. The results showed that all the brands complied with Pharmacopoeial standards except tablets from one brand that could not release up to 75 % of its ciprofloxacin content within 45 minutes. This suggests good regulation of the pharmaceutical sector.
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