PREPARATION AND IN VITRO EVALUATION OF HYDROXYAPATITE-SODIUM ALGINATE NANOCOMPOSITE FOR SUSTAINED DELIVERY OF DOXORUBICIN
ONOYIMA CC1*, OKIBE FG2, AGBAJI EB2
1Department of Chemistry, Nigeria Police Academy, Wudil, Nigeria
2Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
Afr. J Pharm Res Dev; Volume 9(2): 154-161; Nov/Dec 2017
ABSTRACT
This study was aimed at preparation of hydroxyapatite-sodium alginate nanocomposite and evaluation of its ability to sustain the release of doxorubicin and eliminate its dose-limiting toxicities. In situ preparation of hydroxyapatite-sodium alginate nanocomposite (HASA) was carried out by the wet chemical precipitation method. Drug loading was carried out at neutral pH, while in vitro drug release study was carried out in synthetic body fluid (SBF) at pH 7.4 and 37 0C. The result of drug loading study showed that the nanocomposites have high loading efficiency for doxorubicin, which increased with increase in sodium alginate composition reaching a maximum value of 92.03% for HASA-50%wt. There was sustained release of doxorubicin by the nanocomposites with sodium alginate composition of 5%wt and above for about 57 hours. The release rate decreased with increase in sodium alginate composition. The result of profile comparison indicates that the following release profiles are similar: HASA-5%wt and HASA-20%wt, HASA-20%wt and HASA-33%wt, HASA-33%wt and HASA-50%wt. The incorporation of sodium alginate to the nano-hydroxyapatite improved its ability to load and release doxorubicin.
KEYWORDS: Doxorubicin, Drug delivery, Hydroxyapatite, Nanocomposite, Sodium alginate,
*Corresponding author: krissonoss@yahoo.co.uk;