COMPARATIVE PHYSICOCHEMICAL AND RHEOLOGICAL EVALUATION OF EXTRACTED AND CARBOXYMETHYLATED PARKIA BIGLOBOSA MUCILAGE

COMPARATIVE PHYSICOCHEMICAL AND RHEOLOGICAL EVALUATION OF EXTRACTED AND CARBOXYMETHYLATED PARKIA BIGLOBOSA MUCILAGE

 
NA’ANMAN CHARLES DAGOGOT1, ZWANDEN SULE YAHAYA2,*,HASSAN MUSA1, TERYILA SUZANNE ALLAGH1, ABDULLAHI Y. IDRIS3
  1. Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University, Zaria, Nigeria.
  2. Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria.
  3. Department of Pharmaceutical and Medicinal chemistry, Ahmadu Bello University, Zaria, Nigeria.

Afr. J Pharm Res Dev; Volume 12(3): 322-332 (2020)

ABSTRACT

Parkia biglobosa gum and mucilage are versatile plant products which are mostly used in food as well as in pharmaceutical industries and can easily be carboxymethylated to modify their physicochemical characteristics. This work aimed to evaluate the physiochemical and rheological properties of the mucilage from Parkia biglobosa seeds. The mucilage was extracted from Parkia biglobosa seeds and modified by carboxymethylation via the Williamson´s synthesis using monochloroacetic acid as the etherifying agent. Physico-chemical characeterization was carried out on the modified mucilage via viscosity and swelling capacity investigation and for its degree of substitution via titrimetric, Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (DSC) techniques. Hydration capacity, moisture sorption, scanning electron microscopy, rheological and flow properties were used to characterize the mucilage. Both mucilages had desirable pleasant odours and bland taste. The extracted mucilage produced a derivative with higher hydration and moisture sorption capacity, a marked decrease in viscosity, and improved flow properties. Also, changes attributable to modification were observed from the FT-IR spectra and DSC thermograms. Both the extracted and modified mucilage possessed fundamental characteristics that would make them suitable as pharmaceutical excipients in the formulation of solid and liquid dosage forms.

Email of correspondence: pharmzwanzy@gmail.com; 

KEYWORDS: Parkia biglobosa; Mucilage; Carboxymethylation; Physicochemical; Rheology.