A NEW ANTIOXIDANT AND ANTIMICROBIAL COMPOUND ISOLATED FROM ALCHORNEA CORDIFOLIA LEAVES
Festus B.C. Okoye1*, Damian C. Odimegwu2, Chukwunonso Nnamdi Anyasor1, Daniel L. Ajaghaku3, Thaddeus H. Gugu4, Patience O. Osadebe5, Peter Proksch6*
1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, 420281 Awka, Anambra State, Nigeria
2 Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001 Nsukka, Enugu State, Nigeria
3 Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, 420281 Awka, Anambra State, Nigeria
4 Department Pharmaceutical Microbiology & Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria
5 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001 Nsukka, Enugu State, Nigeria
6 Institut für Pharmazeutische Biologie und Biotechnologie, Universität Düsseldorf, Düsseldorf, Germany
Afr. J Pharm Res Dev; Volume 7(2): 87-94; Nov/Dec 2015
ABSTRACT
A new luteoyl derivative, 1-O-galloyl-6-O-luteoyl-β-D-glucopyranoside, together with five known compounds were isolated from the methanol leaf extract of Alchornea cordifolia. The chemical structures of these compounds were confirmed by 1D and 2D NMR and HRMS analyses. The compounds exhibited significant antioxidant activity with IC50 values in the range of 1.56 to 3.11 μg/ml. Some of the activities were comparable to that of ascorbic acid (IC50 value of 1.56 μg/ml). The compounds also exhibited good antimicrobial activity against Escherichia coli with MIC values in the range of 105 to 180 μg/ml. The fraction from which these compounds were isolated, however, showed broad spectrum antimicrobial activity comparable to ciprofloxacin. This fraction also showed no toxicity against Hep 2 cell lines. In conclusion, extract of A. cordifolia leaves and the isolated compounds exhibited very strong anti-oxidant as well as antimicrobial activity. These activities further support the ethnomedicinal uses of this plant material.
Email of correspondence: fb.okoye@unizik.edu.ng