ASCORBIC ACID IN COMBINATION WITH AMOXICILLIN IMPROVES ACUTE ENDOMETRITIS IN MURINE MODELS
BAFOR ENITOME EVI*1, OMORUYI OSEMELOMEN1, OCHOYAMA EJIROGHENE1, ITEMIRE ANNE OGHENEKEVWE2
1.Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria.
2.Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City, Edo State Nigeria.
Afr. J Pharm Res Dev; Volume 12(2): 233-241 ; 2020
Endometritis, refers to uterine lining inflammation which is a common postpartum infection that can cause uterine rupture in pregnancy. This study investigated the outcome of combining ascorbic acid (AA) with amoxicillin (AMX) in a mouse model of endometritis. Regular cycling mice were inoculated with E. coli and placed in different experimental groups. After E. coli inoculation, treatment was administered for five days. Group 1 received AA (100 mg/kg) and AMX (500 mg/kg); group 2 received AA (1000 mg/kg) and AMX (500 mg/kg) and group 3 received ibuprofen (400 mg/kg) and AMX (500 mg/kg). Estrous cycling, body temperature, and body weights were assessed. At the end of the experiment, blood samples and uteri were collected and assessed. Uterine contractility was also measured as an indicator of function. AA (1000 mg) + AMX (500 mg/kg) combination restored estrous cyclicity, improved body temperature, restored uterine organ weights, and increased leukocytic parameters. The uterine architecture was also restored, and uterine function was improved. This study shows that combination therapy with AA and AMX provides a better therapeutic option in the management of endometritis.
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KEYWORDS: Endometritis, Ascorbic Acid, Combination Therapy, Amoxicillin, Uterus, Ibuprofen.