ASSESSMENT OF PHYSICOCHEMICAL PROPERTIES OF GLIBENCLAMIDE TABLETS MARKETED IN ZARIA, KADUNA STATE, NIGERIA
NAFIU AMINU1,*, WAKILI IBRAHIM ADO2, HASSAN MUSA2, MOMOH A. MUMUNI3, MAHMUD S. GWARZO4
1.Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, P.M.B. 2346, Nigeria.
2.Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
3.Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
4.Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Bayero University Kano, Nigeria.
Afr. J Pharm Res Dev; Volume 12(2): 242-247 ; 2020
ABSTRACT
This study analyzed six commercially available glibenclamide tablets marketed in Zaria, Nigeria, for quality in terms of content of active ingredients and some physicochemical parameters. The conducted tests were weight variation, thickness, diameter, friability, disintegration time, and assay of active content by UV spectrophotometer. The tests were performed as described by official books. Glibenclamide tablet samples were randomly purchased from pharmacy outlets and patent medicine stores, and they comprised samples manufactured in Nigeria and other countries. The results showed that all the samples passed the weight variation, disintegration time, thickness, and diameter tests. Four out of the six brands passed assay of active content, as they satisfied the BP specifications which required glibenclamide content to be between 95 to 105%, while one of the six tested brands failed the friability test. Overall, only 50% of the tested samples passed the quality control assessment.
Email of correspondence:nabgus@yahoo.com;
KEYWORDS: Quality control assessment, Glibenclamide tablets, Zaria, Diabetes mellitus, Substandard drugs.