COLORECTAL CANCER AND ASPIRIN: A LITERATURE REVIEW
Bashir AIJ1*, Nicholl ID2
1Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna-Nigeria
2Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton, WV1 1LY, UK
Afr. J Pharm Res Dev; Volume 10(2): 060-078 ; 2018
The rise in the prevalence of colorectal cancer (CRC) in Nigeria and the world as a whole is of great concern. Metastatic colorectal cancer (mCRC) in particular is still difficult to treat resulting in poor prognosis. Evidence suggests that the NSAID, aspirin, has the potential to decrease incidence of, or mortality from, a number of cancers through several mechanisms of action, which has led to the recommendation of low dose aspirin for the prevention of CRC by the Unites States Preventative Services Task Force. This literature review looks into the hallmarks of cancer, types and pathways of colorectal cancer with emphasis on the different treatments, clinical trials. It also looks into the different proposed mechanisms of action that aspirin follow to execute its effect on the growth of cancer cells with the hope that it will also be adopted as a standard in the chemoprevention of colorectal cancer in Nigeria. This paper will hopefully serve as a reference point for interested researchers that are especially new to this field.
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KEYWORDS: Aspirin, colorectal cancer, chemotherapy, immunotherapy, metastatic colorectal cancer.