EFFECT OF ETHANOL LEAF EXTRACT OF Cassia angustifolia EXTRACT ON HEART AND LIPID PROFILE OF WISTER RATS
WAZIS CHAMA HARUNA1, JOSEPH OYEPATA SIMEON2, *, MODUPE BUILDERS2 , JOSEPH OPEYEMI TOSIN3
1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Bornu State, Nigeria.
2. Department of Pharmacology, Faculty of Pharmacy, Bingham University, Nasarawa, Nigeria.
3. Department of Pharmacology, Faculty of Basic Medical Sciences, University of Port Harcourt, Rivers State, Nigeria.
Afr. J Pharm Res Dev; Volume 12(1): 048-055 ; 2020
The human heart is an organ that pumps blood throughout the body via the circulatory system, supplying oxygen and nutrients to the tissues and removing carbon dioxide and other wastes. Damage to tissue or cells of the heart can be very fatal. Cassia angustifolia is a plant regularly consumed by the locals to treat gastrointestinal issues. The aim of this study is to determine the effect of Cassia angustifolia on the heart and other cardiovascular parameter. Animals of either sex were selected. Group 1 received distilled water (10 ml/kg), while group 2, 3 and 4 received Cassia angustifolia 50, 100 and 200 mg/kg respectively. Animals were kept in standard cages and given access to the extract, water and food orally for 28 days, after which they were weighed and sacrificed. Blood was collected by cardiac puncture and taken immediately for hematological and chemo pathological analysis. The histological toxic potential of the plant on the kidney was studied using haematotoxylin and eosin (H&E) staining technique. There was significant (P<0.05) decrease in RBC, HGB, MCV, while there was no change in the level of neutrophiles, basophiles, eosinophiles and platelets. The extract did not cause significant (P<0.05) change in the level of cholesterol, low density lipoprotein (LDL) and triglyceride. There was significant (P<0.05) increase in the level of high-density lipoprotein (HDL). Histological observation revealed slight to no damage to tissue of the heart. Result obtained suggests that the plant maybe of cardiovascular significance, particularly when taken for a prolong period of time.
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KEYWORDS: Cassia angustifolia, heart, rat, cholesterol.