EFFECTIVE AND INNOVATIVE TECHNOLOGIES AND DEVICES FOR QUALITY ASSURANCE OF LIQUID DRUG DELIVERY SYSTEMS, LDDS. I PARACETAMOL SYRUP IN NIGERIA CLINICS AND PHARMACIES
Chukwu UA*1, Chukwu OA2, Chukwu A3
1 Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka
2 Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, U.N.N and Pharmacoeconomics, Health policy Research and Development Pharmaceutical Services Department, National Assembly, Abuja
3 Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001, Nsukka, Enugu State
Afr. J Pharm Res Dev; Volume 9(1): 93-95; June/July 2017
ABSTRACT
In this work, we are interested in researching and developing cheap and accurate techniques that will be used to detect genuine or fake liquid drug delivery systems, LDDS in the market, clinics and pharmacies in Enugu, Nigeria. The World Health Organisation, WHO and regulatory agencies such as NAFDAC in Nigeria encourages research and development of Pharmaceutical and Medical devices for quick detection of genuine and fake products especially in developing countries. A calibrated Perspex cylindrical measure was used to release drops of paracetamol syrup from a fixed height of 6cm above a white horizontal paper board. The time taken for 10 drops of the syrup to fall under gravity from a 21 G * 1.5” Hypoject – IV needle was determined. The mean-time, t was calculated for each batch. The CV% and SDs were recorded. It was characteristic for each batch of Paracetamol syrup from a particular manufacturer. The experiments carried out at 27 +/- 1 degrees Celsius in an undisturbed environment showed that genuine products that are not decomposed had mean time that are similar for each product. EP brand of the syrup had a t value of 47.29 +/- 17.46 seconds and CV% of 36.92 per the stable product as against the value of 1.88 +/- 0.47 seconds showing a gross decrease in viscosity. We conclude that this simple technology can be used in challenged hospital clinics, community pharmacies, primary health care centres and laboratories for paracetamol syrup standardisation per manufacturer. It can also be used to compare different brands for rejection or acceptance.
KEYWORDS: Effective, Innovative, Devices, Quality assurance, Paracetamol syrup
Email of correspondence: binyerem1@gmail.com