EVALUATION OF ANTIBACTERIAL EFFECTS OF Ficus cycomorus EXTRACTS ON DRUG
RESISTANT Yersinia enterocolitica ISOLATES ASSOCIATED WITH APPENDICITIS IN KANO STATE- NIGERIA
YAHAYA SHEHU MOHAMMED1*, AISHATU AMINU IBRAHIM2, ALIYU USMAN DUSTINMA2,
MOHAMMAD DAUDA MUKHTAR2
- College of Nursing Sciences, Kano State.
- Department of Microbiology, Bayero University, Kano
Afr. J Pharm Res Dev; Volume 17(3): 385-391; 2025
ABSTRACT
The study aimed at evaluating the effects of Ficus cycomorus extracts on resistant Yersinia enterocolitica isolates associated with appendicitis, processed and unprocessed meat samples in Kano state, Nigeria. Hospitals where appendectomies and laparotomies were carried out were randomly selected for the collection of appendiceal and stool samples from one hundred and ten patients (110) using a judgmental sampling technique making total samples two hundred and twenty (220). One hundred and twenty (120) both processed (60) and unprocessed (60) meat samples were randomly collected for processing using culture and biochemical test (API 20E SYSTEM). The antibiogram, phytochemical screening, toxicity, and antibacterial activity of the plant extract against the isolates were also determined. The study revealed that Yersinia enterocolitica isolates from appendiceal and stool samples were found to be sensitive to gentamicin, ciprofloxacin, cefixime, chloramphenicol, and ceftriaxone, and resistant to ampicillin. In contrast, the isolates from unprocessed and processed meat samples were found to be sensitive to ampicillin, tetracycline, and cefixime, and resistant to chloramphenicol. The study revealed no significant difference in terms of susceptibility pattern of the isolates to conventional antibiotics (p = 0.2). The study revealed an insignificant difference (p = 0.2) for the extract of Ficus cycomorus on the isolates and the tolerability of the plant extracts for human use.
Keywords: Ficus sycomorus, Yersinia enterocolitica, Meat samples, Appendicitis, Antibiogram
Email of correspondence: yahayashehu87@gmail.com;
https://doi.org/10.59493/ajopred/2025.3.15 ISSN: 0794-800X (print); 1596-2431 (online)