EVALUATION OF PHYTOCHEMICAL AND ANTI-INFLAMMATORY EFFECTS OF METHANOL EXTRACT OF Borreria stachydea [(DC) Hutch. and Dalziel] (Rubiaceae)
Anas A1*, Ambi AA2, Zainab M2, Saleh MIA3, Nazifi AB4
- Department of Pharmacognosy and Herbal Medicine, Bayero University Kano, Kano State– Nigeria.
- Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria – Nigeria.
- Department of Human Physiology, Ahmadu Bello University Zaria, Kaduna State – Nigeria.
- Department of Pharmacology and Therapeutics, Bayero University Kano. Kano State– Nigeria.
Afr. J Pharm Res Dev; Volume 11(1): 066-073 ; 2019
Borreria stachydea [(DC) Hutch. & Dalziel] is an erect, hairy and weedy herb, about 1ft in height with mauve flowers. It belongs to the phylum magnoliophyta, and its class is magnoliopsida and a member of the Rubiaceae family. It is found in Nigeria, Ghana, Sudan, Malaysia, India and several other nations of the world. This studies was primarily aimed to evaluate the qualitative and quantitative phytochemical evaluation of primary and secondary metabolites, toxicity studies, acute and chronic anti-inflammation using standard method which reveals the presence of carbohydrates, cardiac glycoside, flavonoids, saponins, steroids, triterpenes and tannins were present in the crude extract. Toxicity studies by using oral route showed no death or any signs of toxicity in any group at 5000 mg/ kg indicating its safety. Anti-inflammatory effects indicates its efficacy at 125 mg/kg at 2 hours and 4 hours, 250 and 500mg/kg in the same hours with the percentage of inhibition of 90.94, 90.21 and 88.04, % compared to standard drug that have 97.10 %. Collectively or individually the phytoconstituents present in this plant attributed to its safety and epicacy. However, this supports the ethnomedical claim of the use of the plant in management of inflammatory condition.
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KEYWORDS: Anti-inflammatory, Borreria stachydea, Phytochemicals, Toxicity