FORMULATION AND EVALUATION OF MUCOADHESIVE CIPROFLOXACIN TABLET USING SIDA ACUTA GUM
*Okafo SE, Okedu O, Alalor C
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Delta State University, Abraka
Afr. J Pharm Res Dev; Volume 9(1): 40-48; June/July 2017
ABSTRACT
Mucoadhesion is the adhesion or sticking together of two or more materials, at least one of which is a mucosal surface. This study was carried out to formulate and evaluate mucoadhesive ciprofloxacin matrix tablets using Sida acuta gum as polymer. Sida acuta gum was extracted from the dried powdered leaves of Sida acuta plant by isopropyl alcohol precipitation of the filtrate obtained from its maceration in distilled water. Different concentrations of Sida acuta gum (10%, 20%), carbopol (10% and 20%) and combination of both (10%/10%) were used respectively as mucoadhesive polymer matrix former. The mucoadhesive matrix tablets were prepared using the direct compression technique. The prepared tablets were evaluated for hardness, weight uniformity, friability, in vitro drug release and mucoadhesive strength. The study showed that the formulations had hardness values ranging from 9.87 to 16.55 kgf while the friability ranged from 0.1 to 0.4 %. About 70 % of their drug contents were released between 0.75 and 8 h. Tablets from all the formulations were able to adhere to the tissue with the duration of adhesion ranging from 4.03 to > 9 h. The kinetics of release showed that Higuchi, first order, Hixson-Crowell and Korsmeyer-Peppas models were in operation but Higuchi was dominant in F2 and F5 while first order and Hixson-Crowell were dominant in F3 and F4 respectively. The mechanism of release was anomalous (non – Fickian) diffusion. Sida acuta gum could be used as a polymer in the formulation of mucoadhesive ciprofloxacin matrix tablets that are comparable to that formulated using carbopol.
KEYWORDS: Ciprofloxacin, matrix tablet, mucoadhesive property, Sida acuta gum
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