FORMULATION AND IN VITRO CHARACTERIZATION OF IBUPROFEN-LOADED SOLID DISPERSIONS
MUMUNI AUDU MOMOH1, *, FRANKLIN CHIMAOBI KENECHUKWU1 , CHINEKWU SHERRIDAN NWAGWU1 , PHILIP UZOR2 , VINCENT OBIEZE1 , AMINU NAFIU3 , OYENIYI JAMES3 , ANTHONY CHIBUZO OFOMATAH4 , ABDULMUMINU ISAH5 , SANNI MUHAMMAD SALIHU6 .
1. Drug Delivery and Nanomedicines Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu, Nigeria.
2. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences University of Nigeria Nsukka, Enugu State, Nigeria.
3. Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Sokoto State.
4. National Centre for Energy Research and Development, University of Nigeria Nsukka, Enugu State, Nigeria.
5. Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria.
6. Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna State, Nigeria.
Afr. J Pharm Res Dev; Volume 12(1): 056-069 ; 2020
The purpose of the study was to formulate solid dispersions of ibuprofen using binary mixtures of Gelucire 50/13 and HPMC by fusion and solvent evaporation methods in order to improve physical and mechanical characteristics of this drug. The dispersions were prepared with the excipients mixtures in the ratios of 1:1, 1:2, 1:4, 2:1 and 4:1 and characterized by determining the Fourier transform infra-red (FTIR) spectroscopy, solubility, entrapment efficiency (EE) and in vitro dissolution rate. The results showed that the EE decreased with increase in the concentrations of both Gelucire 50/13 and HPMC in the dispersions. Batch C containing Gelucire 50/13 and HPMC in the ratio 1:4 respectively showed the highest solubility for the fusion and solvent evaporation methods. Results of the FTIR spectroscopy study showed that there was no remarkable difference between the spectra of ibuprofen in the solid dispersions, physical mixtures and that of the pure sample of drug. The batches prepared by fusion method gave higher release rate in both SIF and SGF compared to those of solvent evaporation. Also, the solid dispersions showed higher release profiles than the commercial sample of ibuprofen. Thus, the Gelucire 50/13 and HPMC (ratio; 1:4, respectively) based ibuprofen solid dispersions represents a promising tool for improving of the solubility of Ibuprofen.
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KEYWORDS: Solid dispersion; Ibuprofen; Gelucire; HPMC (hydroxypropylmethylcellulose); Fourier transform infra-red (FTIR) spectroscopy.