Functional Properties of Amoxicillin Encapsulated in Niosomes or Liposomes


Ebele B. Onuigbo*, Jacinta Eze, Anthony A. Attama

Department of Pharmaceutics, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria

Afr. J Pharm Res Dev; Volume 7(2): 66-71; Nov/Dec 2015

The functional properties of amoxicillin encapsulated in drug delivery systems (anionic niosomes, cationic liposomes and anionic liposomes) were investigated. Each of the novel drug delivery systems were made in three runs using different molar ratios of anionic niosomes 100:100:10, 400:100:10 and 150:300:10 (Tween 20:cholesterol:dicetyl phosphate), anionic liposomes of 75:75:10, 75:150:10, 100:300:10 (cholesterol: phospholipids: dicetylphosphate), cationic liposomes of 100:100:10, 75:150:10, 100:300:10 (cholesterol: phosphatidylcholine: stearylamine). The susceptibility of three clinical isolates to the drug delivery systems encapsulating amoxicillin was carried out using agar diffusion method. Also, physicochemical studies such as morphology, particle size and stability studies were assessed. The results of the susceptibility of the clinical isolates showed a sustained release from the delivery systems. Morphology of niosomes revealed spherical shaped vesicles. For the particle size determination, all the batches gave mean particle size diameter below 3.8 µm. Stability studies carried out on each of the different unlyophilized drug formulations kept at 28 ˚C and at 40 ˚C after two weeks showed destabilization while those kept at 4˚C were very stable for two weeks. Differential scanning calorimetry was also performed

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