FUNDAMENTAL PROPERTIES OF Prosopis africana PEEL POWDERS (PAPPS) AS DRUG DELIVERY EXCIPIENT
PETRA OBIOMA NNAMANI1,4 , ANILKUMAR JALINDAR SHINDE2 , NAMDEO RAMHARI JADHAV2 , MONICA RAJAN SANANDAM3 AND CHANDRAKANT DNYANDEV LOKHANDE4
1. Drug Delivery and Nanomedicines Research Unit; Public Health and Environmental Sustainability (PHES) Research Group, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu, Nigeria.
2. Department of Pharmaceutics, Bharati Vidyapeeth, College of Pharmacy, Near Chitranagari, Kolhapur- 416013, Maharashtra, India.
3. KIT’s College of Engineering, Kolhapur- 411038, Maharashtra, India.
4. Thin film Physics Laboratory, Department of Physics, Shivaji University, Kolhapur- 416 004 Maharashtra, India.
Afr. J Pharm Res Dev; Volume 12(1): 119-133 ; 2020
ABSTRACT
Biodegradable Prosopis africana peel powders (PAPPs) are effective excipients to achieve amorphous drug delivery better than β-cyclodextrin and Gelucire 50/13. In this study, we investigated the fundamental properties of PAPPs as powders through solid micromeritics determination, solid state characteristics of size, shape, thermal property, interaction study and level of crystallinity as well as dispersion properties through pH evaluation, viscosity and solution properties in bio-relevant media. Results showed that PAPPs had good flow properties and existed as micropowders more amorphous (3.3 J/g and 9.77 J/g) than β-cyclodextrin and Gelucire 50/13. They interacted by OH-bond and amino group but more specifically, their possession of Sulphur-containing (S-H) moiety explained why they yielded little residue upon solution. PAPP A2 showed frothing habit of surfactant action and was more chemically stable than PAPP A1; both better than β-cyclodextrin and Gelucire 50/13.
Email of correspondence: petra.nnamani@unn.edu.ng;
KEYWORDS: Prosopis africana; β-cyclodextrin; Gelucire 50/13; FTIR/FT-Raman; Powder X-ray diffraction.