ISOLATION AND CHARACTERIZATION OF TWO PENTACYCLIC TRITERPENOIDS FROM GLOSSONEMA BOVEANUM DECNE (APOCYNACEAE)
Shehu S1*, Abubakar MS1, Musa AM2, Tajuddeen N3, Zakariya AM1
1 Department of Pharmacognosy and Drug Development, ABU Zaria, Nigeria
2 Department of Pharmaceutical and Medicinal Chemistry, ABU Zaria, Nigeria
3 Department of Chemistry, ABU Zaria, Nigeria
Afr. J Pharm Res Dev; Volume 7(2): 72-76; Nov/Dec 2015
ABSTRACT
Two pentacyclic triterpenes α-amyrin acetate and lupeol were isolated from the n-hexane soluble fraction of the aqueous ethanol extract of the aerial parts of Glossonema boveanum, a plant used in traditional medicine for the treatment of epilepsy and stimulation of lactation using a combination of silica gel column chromatography and preparative TLC. The structures of these compounds were elucidated using NMR spectroscopic analysis (1D& 2D) and by comparison with reported data. This is the first report of isolation of these compounds from this plant and its genus.
*Author for correspondence: shehus3621@yahoo.com