PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES OF ROOT BARK EXTRACTS FROM GLOSSONEMA BOVEANUM (DECNE)
Ahmed Jibrin Uttu*, Waziri Maimuna
Department of Chemistry, Federal University Gashua, Yobe State, Nigeria
Afr. J Pharm Res Dev; Volume 9(2): 112-118; Nov/Dec 2017
The root bark of Glossonema boveanum (Decne), a member of Apocynaceae family, is use by traditional medicine practitioner to treat urinary and respiratory tract infections, bacteremia, typhoid fever, bacillary dysentery, diarrhoea and stomach pain. This present study is aim to validate the medicinal claims ascribed to the root bark of the plant. Preliminary phytochemical study of the root bark extracts (n-hexane, ethyl acetate, chloroform and methanol extracts) showed the presence of alkaloids, carbohydrates, steroids, triterpenes, cardiac glycosides, saponins, tannins and flavonoids. Antimicrobial study of the extracts showed activities against Staphylococus aureus, Bacillus subtilis, Salmonella typhii, Shigella dysenteriae, Escherichia coli, Enterobacter cloacae, Streptococcus agalactiae and Candida albicans while Micrococcus luteus, Pseudomonas aeruginosa and Klebsiella Pneumoniae showed resistance to all the extracts. The inhibitory effect was compared with the standard drug ciprofloxacin and fluconazole. MIC and MBC for both extracts were also determined using the tube dilution method. This study concluded that the root bark of G. boveanum, used traditionally as a medicinal plant, has antimicrobial activities against some causative organisms.
KEYWORDS: Glossonema boveanum (Decne.), phytochemical, antimicrobial, minimum inhibitory concentration, minimum bactericidal concentration
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