PHYTOLIPIDS LIPOSPHERES FORMULATION: APPLICATION IN ORAL DELIVERY OF METFORMIN HYDROCHLORIDE TO DIABETIC RATS
Mumuni A. Momoh*1, Kenechukwu F. Chimaobi1, Akpabio E. Ibanga2
- Drug Delivery Unit, Department of Pharmaceutics, University of Nigeria Nsukka, Enugu State, Nigeria
- Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Akwa-Ibom State, Nigeria
Afr. J Pharm Res Dev; Volume 7(2): 124-136; Nov/Dec 2015
The antidiabetic activity of oral metformin is dependent on its bioavailability. The purpose of the research is to improve the solubility, bioavailability and therapeutic efficacy of metformin using structure lipospheres. Dika fat was extracted from Irvingia gabonensis var. excelsa (Irvingia wombolu), and matrix consist of Dika fat with soyabean oil 3:1 was prepared and thereafter use to formulated lipospheres loaded with increase concentration of metformin. The formulated lipospheres were characterized in vitro. In vivo antidiabetic activity of metformin-loaded lipospheres was evaluated in hyperglycemic rats. The result of our findings showed that Matrix from the lipid mixture generated a structural disoriented matrix with numerous spaces that accommodated metformin in a concentration-dependent manner with maximum DEE of 87 %. The particle sizes were in micro range (10.45-21.22 µm) and there were no significant changes in the pH (6.1-5.8) of the formulations, indicating stable preparation. Maximum blood glucose–lowering effect (76.22 %) of the lipospheres was comparably higher than the conventional formulation (54.89 %).
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