PREPARATION, OPTIMIZATION, CHARACTERIZATION AND STABILITY STUDIES OF NIOSOMAL-BASED AMOXICILLIN
*Ebele B Onuigbo and Jacinta C Eze
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences,
University of Nigeria, Nsukka, 410001, Nsukka, Enugu State, Nigeria
Afr. J Pharm Res Dev; Volume 8(1): 54-63; June/July 2016
ABSTRACT
This study determines the optimum process in preparation of niosomes containing amoxicillin. Varying binary molar ratios of cholesterol and non-ionic surfactants were evaluated for encapsulation efficiency. The batch with the highest encapsulation efficiency was optimized by studying their drug release using varying hydration volumes and hydration time. Stability studies were carried by storing the niosomes for three months at 4°C, 27 °C and 37 °C and assessing their colour changes, sedimentation and pH under these conditions. Results show that Tween 80 niosome comprising 1:3 molar ratios of Tween 80 and cholesterol had the highest encapsulation efficiency of 41.61 %. Optimization of the preparation using varying hydration volume and time showed that the niosome followed mostly a zero order kinetics. Stability studies showed varying degrees of stability at various temperatures.
*Corresponding Author: ebele.onuigbo@unn.edu.ng