SELF-EMULSIFYING DRUG DELIVERY SYSTEM BASED ON INDIGENOUS BREADFRUIT SEED OIL FOR ENHANCEMENT OF AQUEOUS SOLUBILITY OF ACECLOFENAC

SELF-EMULSIFYING DRUG DELIVERY SYSTEM BASED ON INDIGENOUS BREADFRUIT SEED OIL FOR ENHANCEMENT OF AQUEOUS SOLUBILITY OF ACECLOFENAC


ROMANUS CHIJIOKE OMEH1,6,*, IBEABUCHI JUDE ALI2 , CYRIL CHEKWUBE ADONU3 ,

ASSUMPTA ADAOBI OMEH4 , AUDU MUMUNI MOMOH5 , GODSWILL CHUKWUNWEIKE

ONUNKWO6 , JACOB OKWUCHUKWU ONYECHI6

  1. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Enugu  State University of Science and Technology, Enugu State, Nigeria
  1. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Enugu State University of          Science and Technology, Enugu State, Nigeria
  1. Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Enugu          State University of Science and Technology, Enugu State, Nigeria. 
  2. Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria.
  3. Drug Delivery Unit, Department of Pharmaceutics, University of Nigeria Nsukka, Enugu State, Nigeria.
  4. Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka, Enugu State, Nigeria

Afr. J Pharm Res Dev; Volume 14(3): 145-161 ; 2022

ABSTRACT

The objective of the current work was to design and characterize aceclofenac-loaded breadfruit seed oil-based self-emulsifying drug delivery systems (SEDDS) with intent to improve the gastrointestinal fluid solubility of the drug. The breadfruit oil was extracted by the soxhlet solvent extraction technique. The oil was then characterized for acid, iodine, peroxide and saponification values. The solubility of aceclofenac in the breadfruit oils and in some selected potential components of the SEDDS was determined by the super saturation technique. Optimization of SEDDS formulation was achieved with the aid of pseudo ternary phase diagrams. The formulated SEDDS were characterized for standard SEDDS properties. The acid and iodine values of the oil were 3.40 ± 0.33 and 17.50 ± 0.05 respectively while the peroxide and saponification values were 7.20 ± 0.08 and 236.46 ± 0.02 respectively. Oil analysis revealed the presence of oleic, palmitic and linoleic acids among other constituents. Fourier transform infrared (FTIR) spectroscopy suggested no drug-excipient incompatibility. The optimized formulation exhibited average globule size of 84.67 ± 0.33 nm, zeta potential of -37.24 ± 0.04 and polydispersity index of 0.203. The SEDDS formulations showed higher in vitro drug releases than both the raw drug and a commercial aceclofenac tablet. The release data fitted more into the Hixson – Crowell model than into other release kinetic models. Based on the results, we concluded that breadfruit oil has the potential to be used as the oil component of a self-emulsifying drug delivery system formulated to enhance the aqueous/gastrointestinal fluid solubility of aceclofenac.

Email of correspondence: romanus.omeh@esut.edu.ng ;

KEYWORDS: Breadfruit oil; Aceclofenac; Self-emulsifying drug delivery system; solid carrier; droplet size.