SURFACE-MODIFIED BEESWAX-BASED NANO-LIPOGELS AS POTENTIAL DRUG DELIVERY SYSTEM: PRELIMINARY PHYSICOCHEMICAL CHARACTERIZATION
Franklin CHIMAOBI KENECHUKWU1,⃰, Mumuni AUDU MOMOH1 , Chukwuebuka HARFORD OZOUDE2 , Anthony AMAECHI ATTAMA1 , Emmanuel CHINEDUM IBEZIM1
- Drug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.
- Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos State, Nigeria.
Afr. J Pharm Res Dev; Volume 11(2): 074-087 ; 2019
Surface-modification is a promising tool in drug delivery. The aim of this study was to prepare and characterize surface-modified nano-lipogels as potential drug delivery system. The nanotool was developed based on mineral fat (beeswax) and surface-modifier [Phospholipon ® 90H (P90H)] and investigated for enhanced physicochemical performance of miconazole nitrate (MN), a poorly water-soluble imidazole antifungal. Differential scanning calorimetry analysis revealed the amorphous nature of the optimized solidified reverse micellar solution (SRMS) containing rational ratio of beeswax and P90H (3:7) used in preparing the solid lipid nano-dispersion (SLN) as well as MN-loaded SRMS. The SLN prepared by high-shear hot homogenization (melt-emulsification) showed irregular and spherical nanoparticles, had low polydispersity indices, with average particle size in the range of 204.0 ± 2.9 to 263.0 ± 7.1 nm. The developed lipid nano-lipogels were spreadable and viscoelastic. Fourier transform infra-red (FT-IR) spectra indicated components compatibility. This study has shown that phospholipid-modified beeswax-based lipid nano-lipogels could be employed as potential drug delivery system to enhance the physicochemical performance of MN.
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KEYWORDS: Physicochemical characterization; Drug delivery system; Solid lipid nano-dispersions (SLNs); Nano-lipogels; Phospholipon® 90H (P90H); Beeswax; Solidified reverse micellar solution (SRMS).